# PDE3B

Source: https://onco.cc/targets/pde3b/  
OnCo record `pde3b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PDE3B (cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms and Essential thrombocythaemia.

## Summary

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signalling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.75, animal model 0.36, genetic association 0.16, clinical 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; HcGIP1
- Tags: cancer-genes-wave
- Symbol: PDE3B
- Class: enzyme
- Biology: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signalling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. Location: Membrane (UniProt). Locus 11p15.2 (HGNC).
- Where found: Myeloproliferative neoplasms: Open Targets association 0.58 with myeloproliferative neoplasm (MONDO_0020076); Essential thrombocythaemia: Open Targets association 0.58 with essential thrombocythemia (MONDO_0005029)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8779: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8779
- UniProt Q13370: https://www.uniprot.org/uniprotkb/Q13370/entry
- NCBI Gene 5140: https://www.ncbi.nlm.nih.gov/gene/5140
- Ensembl ENSG00000152270: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000152270

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Essential thrombocythaemia (ET)](https://onco.cc/cancers/essential-thrombocythaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)

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JSON: https://onco.cc/api/v1/entities/pde3b.json