# PDGFRB

Source: https://onco.cc/targets/pdgfrb/  
OnCo record `pdgfrb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A growth receptor on connective-tissue and blood-vessel cells. Imatinib works in rare cancers driven by PDGFRB fusions, such as dermatofibrosarcoma protuberans and some chronic myeloid neoplasms with eosinophilia.

## Summary

Platelet-derived growth factor receptor beta signals in fibroblasts, pericytes and smooth muscle. The COL1A1::PDGFB fusion of dermatofibrosarcoma protuberans drives the receptor through its own ligand, and PDGFRB rearrangements define a group of myeloid and lymphoid neoplasms with eosinophilia; both respond to imatinib, which inhibits PDGFRB alongside KIT, ABL1 and PDGFRA. Sunitinib, pazopanib and other multi-kinase inhibitors also block it, contributing to their anti-angiogenic effect through pericytes. In most solid tumours PDGFRB is a stromal rather than a tumour-cell target.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Symbol: PDGFRB
- Class: kinase
- Biology: Receptor tyrosine kinase of mesenchymal cells and pericytes; oncogenic through fusions in dermatofibrosarcoma protuberans and myeloid neoplasms with eosinophilia.
- Where found: Dermatofibrosarcoma protuberans (COL1A1::PDGFB); Myeloid or lymphoid neoplasms with PDGFRB rearrangement; Tumour stroma and pericytes

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/PDGFRB
- UniProt P09619: PDGFRB: https://www.uniprot.org/uniprotkb/P09619/entry

## Connected records

- cancers: [Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms](https://onco.cc/cancers/cmml/), [Dermatofibrosarcoma protuberans](https://onco.cc/cancers/dermatofibrosarcoma-protuberans/), [Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL)](https://onco.cc/cancers/all-ph-like/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)
- drugs: [Imatinib](https://onco.cc/drugs/imatinib/), [Sunitinib](https://onco.cc/drugs/sunitinib/)
- key papers: [Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer](https://onco.cc/key-papers/paper-burstein-tnbc-genomic-subtypes-ccr-2015/)

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