# PDGFRL

Source: https://onco.cc/targets/pdgfrl/  
OnCo record `pdgfrl` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like".

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.30, genetic association 0.47, somatic mutation 0.55, animal model 0.43).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: platelet derived growth factor receptor like; Platelet-derived growth factor receptor-like protein; PRLTS
- Tags: cancer-genes-wave
- Symbol: PDGFRL
- Class: other
- Biology: UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like". Location: Secreted (UniProt). Locus 8p22 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8805: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8805
- UniProt Q15198: https://www.uniprot.org/uniprotkb/Q15198/entry
- NCBI Gene 5157: https://www.ncbi.nlm.nih.gov/gene/5157
- Ensembl ENSG00000104213: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104213

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

---
JSON: https://onco.cc/api/v1/entities/pdgfrl.json