# PDLIM5

Source: https://onco.cc/targets/pdlim5/  
OnCo record `pdlim5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1.

Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.61, genetic association 0.64).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: PDZ and LIM domain 5; PDZ and LIM domain protein 5; Enh
- Tags: cancer-genes-wave
- Symbol: PDLIM5
- Class: other
- Biology: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Location: Postsynaptic density; Presynapse; Postsynapse; Cytoplasm, cytosol (UniProt). Locus 4q22.3 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.50 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17468: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17468
- UniProt Q96HC4: https://www.uniprot.org/uniprotkb/Q96HC4/entry
- NCBI Gene 10611: https://www.ncbi.nlm.nih.gov/gene/10611
- Ensembl ENSG00000163110: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163110

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/pdlim5.json