# PEG3

Source: https://onco.cc/targets/peg3/  
OnCo record `peg3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PEG3 (Paternally-expressed gene 3 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.

## Summary

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: paternally expressed 3; Paternally-expressed gene 3 protein; ZKSCAN22; KIAA0287; ZNF904; ZSCAN24
- Tags: cancer-genes-wave
- Symbol: PEG3
- Class: tumor-suppressor
- Biology: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumour suppressing activity in glioma cells. Location: Nucleus; Cytoplasm (UniProt). Locus 19q13.43 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8826: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8826
- UniProt Q9GZU2: https://www.uniprot.org/uniprotkb/Q9GZU2/entry
- NCBI Gene 5178: https://www.ncbi.nlm.nih.gov/gene/5178
- Ensembl ENSG00000198300: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198300

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/peg3.json