# Peritoneal metastasis

Source: https://onco.cc/terms/peritoneal-metastasis/  
OnCo record `peritoneal-metastasis` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Spread across the lining of the abdomen, the most common way stomach cancer recurs and the hardest to treat.

## Summary

Present in ~30% at diagnosis and the leading site of relapse after gastrectomy. Poorly imaged (CT misses low-volume disease; staging laparoscopy is standard), poorly penetrated by systemic drugs. Intraperitoneal paclitaxel (PHOENIX-GC), HIPEC, and PIPAC are under evaluation; CLDN18.2 CAR-T shows activity.

## Fields

- Kind: Term
- Last checked: 2026-09-07

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Peritoneal_carcinomatosis
- Wikipedia: https://en.wikipedia.org/wiki/Peritoneal_carcinomatosis

## Connected records

- cancers: [Advanced and metastatic small bowel adenocarcinoma](https://onco.cc/cancers/advanced-small-bowel-adenocarcinoma/), [Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell)](https://onco.cc/cancers/appendiceal-adenocarcinoma/), [Appendiceal cancer and pseudomyxoma peritonei](https://onco.cc/cancers/appendiceal/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gallbladder cancer](https://onco.cc/cancers/gallbladder/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Goblet cell adenocarcinoma of the appendix](https://onco.cc/cancers/goblet-cell-adenocarcinoma/), [Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei](https://onco.cc/cancers/low-grade-appendiceal-mucinous-neoplasm/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- technologies: [HIPEC / PIPAC (intraperitoneal chemotherapy)](https://onco.cc/technologies/hipec/)
- ideas: [Peritoneal-directed therapy for gastric cancer](https://onco.cc/ideas/idea-peritoneal-directed-gastric/), [Treat the body cavity, not the bloodstream, for surface spread](https://onco.cc/ideas/idea-bio2-intracavitary-immunotherapy/)
- terms: [Cytoreductive surgery](https://onco.cc/terms/cytoreductive-surgery/), [Peritoneal cancer index](https://onco.cc/terms/peritoneal-carcinomatosis-index/), [Peritoneal metastases from bowel cancer](https://onco.cc/terms/colorectal-peritoneal-metastases/), [Port-site metastasis](https://onco.cc/terms/port-site-metastasis/), [Symptom control in advanced gallbladder cancer: pain, ascites and nutrition](https://onco.cc/terms/gallbladder-cancer-symptom-control/)
- bottlenecks: [Metastasis is understood least and studied last](https://onco.cc/bottlenecks/b-metastasis-biology/)
- pathways: [Organ tropism: seed and soil](https://onco.cc/pathways/organ-tropism-seed-soil/)

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JSON: https://onco.cc/api/v1/entities/peritoneal-metastasis.json