# PGAP3

Source: https://onco.cc/targets/pgap3/  
OnCo record `pgap3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PGAP3 is an enzyme gene in the HER2 amplicon that remodels the lipid anchors of cell-surface proteins.

## Summary

17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes PGAP3 as acting in the fatty acid remodelling of GPI anchors, replacing an unsaturated acyl chain with a saturated one.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: post-GPI attachment to proteins phospholipase 3; PERLD1; CAB2
- Tags: cansim-terms
- Symbol: PGAP3
- Class: enzyme
- Biology: Phospholipase involved in the fatty acid remodelling steps of GPI-anchor maturation; ubiquitously expressed, highest in thyroid and placenta (UniProt Q96FM1).
- Where found: Locus 17q12 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:23719: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23719
- UniProt Q96FM1: https://www.uniprot.org/uniprotkb/Q96FM1/entry

## Connected records

- targets: [HER2](https://onco.cc/targets/her2/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/)

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JSON: https://onco.cc/api/v1/entities/pgap3.json