# Ph-positive ALL

Source: https://onco.cc/terms/ph-positive-all/  
OnCo record `ph-positive-all` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Ph-positive ALL is acute lymphoblastic leukaemia carrying the Philadelphia chromosome. It was once the worst kind and is now often the best-controlled, thanks to TKIs and blinatumomab.

## Summary

BCR::ABL1-positive B-ALL, ~25% of adult B-ALL and rising with age. TKI (dasatinib or ponatinib) plus reduced-intensity chemotherapy or steroids alone induces remission in nearly all; PhALLCON showed ponatinib beats imatinib for MRD-negative remission (34.4% vs 16.7%); D-ALBA showed a chemotherapy-free dasatinib-blinatumomab regimen with 95% 18-month survival. Whether transplant in first remission is still needed for MRD-negative patients is the open question.

## Fields

- Kind: Term
- Last checked: 2026-09-07

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Philadelphia_chromosome
- ClinicalTrials.gov NCT03589326: PhALLCON: https://clinicaltrials.gov/study/NCT03589326
- ClinicalTrials.gov NCT02744768: D-ALBA (GIMEMA LAL2116): https://clinicaltrials.gov/study/NCT02744768

## Connected records

- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Philadelphia chromosome-positive acute lymphoblastic leukaemia in children (Ph-positive ALL)](https://onco.cc/cancers/all-paediatric-ph-positive/)
- targets: [BCR::ABL1 (Philadelphia chromosome)](https://onco.cc/targets/bcr-abl/)
- drugs: [Asciminib](https://onco.cc/drugs/asciminib/), [Blinatumomab](https://onco.cc/drugs/blinatumomab/), [Dasatinib](https://onco.cc/drugs/dasatinib/), [Imatinib](https://onco.cc/drugs/imatinib/), [Ponatinib](https://onco.cc/drugs/ponatinib/)
- trials: [D-ALBA (GIMEMA LAL2116)](https://onco.cc/trials/d-alba/), [PhALLCON](https://onco.cc/trials/phallcon/)
- pairings: [BCR::ABL1 TKI + blinatumomab (chemotherapy-free Ph+ ALL)](https://onco.cc/pairings/tki-plus-blinatumomab-ph-all/)
- ideas: [Transplant-free Ph-positive ALL for MRD-negative adults](https://onco.cc/ideas/idea-transplant-free-ph-all/)

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