# PHLDA1

Source: https://onco.cc/targets/phlda1/  
OnCo record `phlda1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PHLDA1 is a growth-factor-responsive gene involved in cell death; it is high in benign moles and falls as melanoma progresses.

## Summary

UniProt describes PHLDA1 (TDAG51) as an apoptosis regulator whose protein is strong in benign naevi and progressively lost in melanoma. The PHLDA family genes are induced downstream of receptor tyrosine kinase and MAPK signalling, which puts them among the MAPK-responsive output genes read from expression.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: pleckstrin homology like domain family A member 1; TDAG51
- Tags: cansim-terms
- Symbol: PHLDA1
- Class: other
- Biology: Involved in regulation of apoptosis, possibly detachment-mediated cell death, and in the anti-apoptotic effects of IGF1; widely expressed, strongly in benign melanocytic naevi and progressively reduced in primary and metastatic melanoma at the protein level (UniProt Q8WV24).
- Where found: Locus 12q21.2 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:8933: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8933
- UniProt Q8WV24: https://www.uniprot.org/uniprotkb/Q8WV24/entry

## Connected records

- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)
- pathways: [RAS / RAF / MEK / ERK (MAPK)](https://onco.cc/pathways/ras-mapk/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/)

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JSON: https://onco.cc/api/v1/entities/phlda1.json