# PHLPP2

Source: https://onco.cc/targets/phlpp2/  
OnCo record `phlpp2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PHLPP2 is a phosphatase that switches AKT off; it is lost in most colorectal cancers, which leaves the survival pathway on.

## Summary

UniProt describes PHLPP2 as the phosphatase that removes the activating Ser-473 phosphate from AKT1 and equivalent sites on PKC, and records that its protein is lost in about four in five colorectal cancers. It is a case where the protein, not the transcript, tells the story: a PI3K/AKT activation state that RNA alone cannot see.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: PH domain and leucine rich repeat protein phosphatase 2; PHLPPL; PPM3B
- Tags: cansim-terms
- Symbol: PHLPP2
- Class: enzyme
- Biology: Protein phosphatase that dephosphorylates Ser-473 of AKT1 and hydrophobic-motif sites of PKC isoforms; expression lost or significantly decreased in about 80 percent of tested colorectal tumours at the protein level (UniProt Q6ZVD8).
- Where found: Locus 16q22.2 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:29149: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29149
- UniProt Q6ZVD8: https://www.uniprot.org/uniprotkb/Q6ZVD8/entry

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)
- pathways: [PI3K / AKT / mTOR](https://onco.cc/pathways/pi3k-akt-mtor/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/), [mRNA to protein concordance](https://onco.cc/terms/mrna-protein-concordance/), [Pathway activation state (phosphosignalling)](https://onco.cc/terms/pathway-activation-state/)

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JSON: https://onco.cc/api/v1/entities/phlpp2.json