# PI4KA

Source: https://onco.cc/targets/pi4ka/  
OnCo record `pi4ka` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.

## Summary

Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phosphatidylinositol 4-kinase alpha; Phosphatidylinositol 4-kinase alpha; PI4K-ALPHA; pi4K230; PIK4CA
- Tags: cancer-genes-wave
- Symbol: PI4KA
- Class: kinase
- Biology: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Location: Cytoplasm; Cell membrane (UniProt). Locus 22q11.21 (HGNC).
- Where found: Mesothelioma: IntOGen driver in 1 cohort (PLMESO); Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8983: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8983
- UniProt P42356: https://www.uniprot.org/uniprotkb/P42356/entry
- NCBI Gene 5297: https://www.ncbi.nlm.nih.gov/gene/5297
- Ensembl ENSG00000241973: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000241973

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Pleural mesothelioma](https://onco.cc/cancers/pleural-mesothelioma/)

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JSON: https://onco.cc/api/v1/entities/pi4ka.json