# Pierre Fenaux

Source: https://onco.cc/people/pierre-fenaux/  
OnCo record `pierre-fenaux` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led AZA-001, which showed azacitidine extends survival in high-risk MDS and made hypomethylating agents standard.

## Summary

Pierre Fenaux (Hôpital Saint-Louis, Paris) was principal investigator of AZA-001, the trial that showed azacitidine improves overall survival compared with conventional care in higher-risk myelodysplastic syndromes, the first drug to do so and the foundation of hypomethylating therapy in MDS and AML. He co-led the European APL trials with Laurent Degos that established all-trans retinoic acid and leads the Groupe Francophone des Myélodysplasies.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: mds; epigenetics; france
- Role: Professor of Hematology, Hôpital Saint-Louis, Université Paris Cité
- Specialisms: Myelodysplastic syndromes; Hypomethylating agents; Acute promyelocytic leukaemia; Older patients with AML

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Fenaux%20P%5BAuthor%5D%20azacitidine%20myelodysplastic

## Connected records

- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)
- technologies: [Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)](https://onco.cc/technologies/epigenetic-drugs/)
- institutions: [Cancer Institute AP-HP Nord, Université Paris Cité](https://onco.cc/institutions/aphp-nord-cancer-institute/)
- key papers: [IMerge: imetelstat, a telomerase inhibitor, for transfusion-dependent lower-risk MDS after erythropoietin has failed](https://onco.cc/key-papers/paper-imerge-imetelstat-mds-lancet-2024/)
- roadmaps: [Epigenetic therapy roadmap: loosening silenced genes → mutation-specific enzymes → editing the epigenome](https://onco.cc/roadmaps/epigenetics-roadmap/)
- trials: [AZA-001](https://onco.cc/trials/aza-001/), [MEDALIST](https://onco.cc/trials/medalist/)

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