# PIK3CG

Source: https://onco.cc/targets/pik3cg/  
OnCo record `pik3cg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PIK3CG (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma, Leukaemia, Acute lymphoblastic leukaemia and 2 more.

## Summary

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signalling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G protein coupled receptor activation to PIP3 production.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes clinical 0.67, affected pathway 0.61, literature 0.99, genetic association 0.30, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Tags: cancer-genes-wave
- Symbol: PIK3CG
- Class: kinase
- Biology: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signalling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarisation and migration by regulating the spatial accumulation of PIP3 and by regulating the organisation of F-actin formation and integrin-based adhesion at the leading edge. Location: Cytoplasm; Cell membrane (UniProt). Locus 7q22.3 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908); Leukaemia: Open Targets association 0.58 with leukaemia (MONDO_0005059); Acute lymphoblastic leukaemia: Open Targets association 0.58 with acute lymphoblastic leukaemia (MONDO_0004967); Chronic lymphocytic leukaemia: Open Targets association 0.57 with B-cell chronic lymphocytic leukaemia (MONDO_0004948); Follicular lymphoma: Open Targets association 0.55 with follicular lymphoma (MONDO_0018906)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.95. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8978: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8978
- UniProt P48736: https://www.uniprot.org/uniprotkb/P48736/entry
- NCBI Gene 5294: https://www.ncbi.nlm.nih.gov/gene/5294
- Ensembl ENSG00000105851: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105851

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/), [Follicular lymphoma](https://onco.cc/cancers/follicular-lymphoma/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/pik3cg.json