# PIK3R5

Source: https://onco.cc/targets/pik3r5/  
OnCo record `pik3r5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.71, affected pathway 0.61, genetic association 0.00, clinical 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phosphoinositide-3-kinase regulatory subunit 5; Phosphoinositide 3-kinase regulatory subunit 5; P101-PI3K; p101
- Tags: cancer-genes-wave
- Symbol: PIK3R5
- Class: other
- Biology: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG. Location: Nucleus; Cytoplasm; Cell membrane (UniProt). Locus 17p13.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30035: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30035
- UniProt Q8WYR1: https://www.uniprot.org/uniprotkb/Q8WYR1/entry
- NCBI Gene 23533: https://www.ncbi.nlm.nih.gov/gene/23533
- Ensembl ENSG00000141506: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141506

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/pik3r5.json