# Pixantrone

Source: https://onco.cc/drugs/pixantrone/  
OnCo record `pixantrone` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Pixantrone is an anthracycline-like drug engineered to spare the heart, approved in the European Union in 2012 as a single agent for adults with aggressive B-cell lymphoma that has relapsed several times.

## Summary

Pixantrone was granted conditional marketing authorisation in the European Union in 2012 for adults with multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma, based on the PIX301 trial in which it produced more complete responses than other single agents. Because it lacks the anthracycline quinone, it causes less cardiotoxicity than doxorubicin in animal models, which allows treatment of patients who have already had a full lifetime dose of anthracyclines. The FDA did not approve it, and the EU authorisation remains conditional pending further confirmatory data.

## Fields

- Kind: Treatment
- Status: approved
- Last checked: 2026-09-08
- Also known as: BBR 2778; Pixantrone dimaleate
- Tags: gap-fill; chembl-universe
- Brand: Pixuvri
- Modality: Aza-anthracenedione cytotoxic, intravenous
- Mechanism: A DNA intercalator and topoisomerase II poison designed to keep the antitumour activity of the anthracyclines while removing the iron-binding quinone that drives their cardiotoxicity.
- Approvals: EU 2012: Multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma, single agent (conditional)

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Pixantrone
- EMA product page: https://www.ema.europa.eu/en/medicines/human/EPAR/pixuvri
- Wikipedia: https://en.wikipedia.org/wiki/Pixantrone
- ChEMBL CHEMBL1201855: https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201855

## Connected records

- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- targets: [Topoisomerase II alpha (TOP2A)](https://onco.cc/targets/top2a/)
- drugs: [Doxorubicin](https://onco.cc/drugs/doxorubicin/)
- companies: [Servier](https://onco.cc/companies/servier/)

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JSON: https://onco.cc/api/v1/entities/pixantrone.json