# PLB-002

Source: https://onco.cc/drugs/plb-002/  
OnCo record `plb-002` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PLB-002 is an experimental antibody-drug conjugate from PrimeLink BioTherapeutics, in phase 1 trials for ovarian cancer, non-small cell lung cancer and CLDN6-positive solid tumours.

## Summary

PLB-002 is an antibody-drug conjugate from PrimeLink BioTherapeutics. An antibody-drug conjugate against Claudin 6, a tight junction protein expressed in some solid tumours (notably ovarian, non-small cell lung, endometrial and testicular cancers) and barely in healthy adult tissue. Built on the company's ENHANMIX platform. Its furthest stage is phase 1, for ovarian cancer, non-small cell lung cancer and CLDN6-positive solid tumours. ClinicalTrials.gov registers it in one study linked below. First patient dosed in phase 1 (company release published 2026-02-26); NCT07304128 recruiting per v2 API. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: PLB-002
- Modality: Antibody-drug conjugate
- Mechanism: An antibody-drug conjugate against Claudin 6, a tight junction protein expressed in some solid tumours (notably ovarian, non-small cell lung, endometrial and testicular cancers) and barely in healthy adult tissue. Built on the company's ENHANMIX platform.

## Sources

- PrimeLink BioTherapeutics: en.primelinkbio.com: http://en.primelinkbio.com/news_detail/13.html
- PrimeLink BioTherapeutics: en.primelinkbio.com: http://en.primelinkbio.com/news_detail/13.html
- PrimeLink BioTherapeutics: primelinkbio.com: https://www.primelinkbio.com/pipeline/1.html
- PrimeLink BioTherapeutics: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT07304128
- ClinicalTrials.gov: trials of PLB-002: https://clinicaltrials.gov/search?intr=PLB-002

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- targets: [Claudin 6](https://onco.cc/targets/cldn6/)
- companies: [PrimeLink BioTherapeutics](https://onco.cc/companies/primelink-biotherapeutics/)
- trials: [A Study of PLB-002 in Advanced Solid Tumors](https://onco.cc/trials/nct07304128/)

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JSON: https://onco.cc/api/v1/entities/plb-002.json