# PLCG1

Source: https://onco.cc/targets/plcg1/  
OnCo record `plcg1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PLCG1 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Renal cell carcinoma, Non-Hodgkin lymphoma and 5 more.

## Summary

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signalling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, genetic association 0.17, somatic mutation 0.91). IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Angiosarcoma, Low-Grade Glioma, NOS, Renal Cell Carcinoma, Soft Tissue.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phospholipase C gamma 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC148; PLC-II; PLCgamma1; NCKAP3; PLC1
- Tags: cancer-genes-wave
- Symbol: PLCG1
- Class: oncogene
- Biology: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signalling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganisation and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyses the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. Location: Cell projection, lamellipodium; Cell projection, ruffle (UniProt). Locus 20q12 (HGNC).
- Where found: Sarcomas: Open Targets association 0.58 with sarcoma (MONDO_0005089); IntOGen driver in 1 cohort (SOFT_TISSUE); Renal cell carcinoma: IntOGen driver in 1 cohort (RCC); Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Adult T-cell Leukaemia/lymphoma; Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:9065: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9065
- UniProt P19174: https://www.uniprot.org/uniprotkb/P19174/entry
- NCBI Gene 5335: https://www.ncbi.nlm.nih.gov/gene/5335
- Ensembl ENSG00000124181: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124181

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Angiosarcoma](https://onco.cc/cancers/angiosarcoma/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Melanoma](https://onco.cc/cancers/melanoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/plcg1.json