# PLCG2

Source: https://onco.cc/targets/plcg2/  
OnCo record `plcg2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PLCG2 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chronic lymphocytic leukaemia.

## Summary

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signalling.

CIViC holds 3 clinical evidence items and 0 assertions across 3 variants, naming Venetoclax.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phospholipase C gamma 2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Tags: cancer-genes-wave
- Symbol: PLCG2
- Class: enzyme
- Biology: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signalling. Location: Membrane raft (UniProt). Locus 16q24.1 (HGNC).
- Where found: Chronic lymphocytic leukaemia: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9066: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9066
- UniProt P16885: https://www.uniprot.org/uniprotkb/P16885/entry
- NCBI Gene 5336: https://www.ncbi.nlm.nih.gov/gene/5336
- Ensembl ENSG00000197943: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197943

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/)

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JSON: https://onco.cc/api/v1/entities/plcg2.json