# PMS1

Source: https://onco.cc/targets/pms1/  
OnCo record `pms1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

Probably involved in the repair of mismatches in DNA.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.38, genetic association 0.76, somatic mutation 0.50, genetic literature 0.01).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: PMS1 homolog 1, mismatch repair system component; PMS1 protein homolog 1; MLH2; PMSL1
- Tags: cancer-genes-wave
- Symbol: PMS1
- Class: other
- Biology: Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt). Locus 2q32.2 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9121: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9121
- UniProt P54277: https://www.uniprot.org/uniprotkb/P54277/entry
- NCBI Gene 5378: https://www.ncbi.nlm.nih.gov/gene/5378
- Ensembl ENSG00000064933: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000064933

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/pms1.json