# PNMT

Source: https://onco.cc/targets/pnmt/  
OnCo record `pnmt` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PNMT makes adrenaline from noradrenaline in the adrenal gland; in breast cancer it matters only because it lies inside the HER2 amplicon.

## Summary

17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes PNMT as the enzyme that converts noradrenaline to adrenaline; its expression in HER2-positive tumours reflects gene dosage, not adrenal biology.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: phenylethanolamine N-methyltransferase; PENT
- Tags: cansim-terms
- Symbol: PNMT
- Class: enzyme
- Biology: Catalyses the transmethylation of noradrenaline to adrenaline using S-adenosyl-L-methionine (UniProt P11086).
- Where found: Locus 17q12 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:9160: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9160
- UniProt P11086: https://www.uniprot.org/uniprotkb/P11086/entry

## Connected records

- targets: [HER2](https://onco.cc/targets/her2/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/)

---
JSON: https://onco.cc/api/v1/entities/pnmt.json