# POLE2

Source: https://onco.cc/targets/pole2/  
OnCo record `pole2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

POLE2 (DNA polymerase epsilon subunit 2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma, Leukaemia, Lung cancer and 5 more.

## Summary

Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, animal model 0.43, genetic association 0.00, clinical 0.99).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DNA polymerase epsilon 2, accessory subunit; DNA polymerase epsilon subunit 2; DPE2
- Tags: cancer-genes-wave
- Symbol: POLE2
- Class: other
- Biology: Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Location: Nucleus (UniProt). Locus 14q21.3 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908); Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059); Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903); Myeloproliferative neoplasms: Open Targets association 0.60 with myeloproliferative neoplasm (MONDO_0020076); Breast cancer: Open Targets association 0.59 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.58 with ovarian cancer (MONDO_0008170)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9178: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9178
- UniProt P56282: https://www.uniprot.org/uniprotkb/P56282/entry
- NCBI Gene 5427: https://www.ncbi.nlm.nih.gov/gene/5427
- Ensembl ENSG00000100479: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100479

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

---
JSON: https://onco.cc/api/v1/entities/pole2.json