# POLE3

Source: https://onco.cc/targets/pole3/  
OnCo record `pole3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

POLE3 (DNA polymerase epsilon subunit 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma, Lung cancer and 5 more.

## Summary

Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.14, genetic association 0.03, clinical 0.99).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DNA polymerase epsilon 3, accessory subunit; DNA polymerase epsilon subunit 3; CHRAC17; Ybl1; p17; CHARAC17; CHRAC2
- Tags: cancer-genes-wave
- Symbol: POLE3
- Class: other
- Biology: Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. Location: Nucleus (UniProt). Locus 9q32 (HGNC).
- Where found: Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908); Lung cancer: Open Targets association 0.59 with lung cancer (MONDO_0008903); Myeloproliferative neoplasms: Open Targets association 0.59 with myeloproliferative neoplasm (MONDO_0020076); Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.58 with ovarian cancer (MONDO_0008170)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13546: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13546
- UniProt Q9NRF9: https://www.uniprot.org/uniprotkb/Q9NRF9/entry
- NCBI Gene 54107: https://www.ncbi.nlm.nih.gov/gene/54107
- Ensembl ENSG00000148229: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148229

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/pole3.json