# POLE4

Source: https://onco.cc/targets/pole4/  
OnCo record `pole4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

POLE4 (DNA polymerase epsilon subunit 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DNA polymerase epsilon 4, accessory subunit; DNA polymerase epsilon subunit 4; p12
- Tags: cancer-genes-wave
- Symbol: POLE4
- Class: other
- Biology: Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Location: Nucleus (UniProt). Locus 2p12 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18755: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18755
- UniProt Q9NR33: https://www.uniprot.org/uniprotkb/Q9NR33/entry
- NCBI Gene 56655: https://www.ncbi.nlm.nih.gov/gene/56655
- Ensembl ENSG00000115350: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115350

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/pole4.json