# POU2AF1

Source: https://onco.cc/targets/pou2af1/  
OnCo record `pou2af1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

POU2AF1 (POU domain class 2-associating factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Lung cancer, Skin cancer and 1 more.

## Summary

Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognises the POU domains of POU2F1/OCT1 and POU2F2/OCT2.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.00, somatic mutation 0.95).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: POU class 2 homeobox associating factor 1; POU domain class 2-associating factor 1; OBF1; BOB1; OCA-B
- Tags: cancer-genes-wave
- Symbol: POU2AF1
- Class: transcription
- Biology: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognises the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centres. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator. Location: Nucleus (UniProt). Locus 11q23.1 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908); Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903); Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898); Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9211: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9211
- UniProt Q16633: https://www.uniprot.org/uniprotkb/Q16633/entry
- NCBI Gene 5450: https://www.ncbi.nlm.nih.gov/gene/5450
- Ensembl ENSG00000110777: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110777

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/pou2af1.json