# POU5F1B

Source: https://onco.cc/targets/pou5f1b/  
OnCo record `pou5f1b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.

## Summary

Shows weak transcriptional activator activity.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.85).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: POU class 5 homeobox 1B; POU domain, class 5, transcription factor 1B; OTF3C; OTF3P1; POU5F1P1
- Tags: cancer-genes-wave
- Symbol: POU5F1B
- Class: transcription
- Biology: Shows weak transcriptional activator activity. Location: Nucleus; Cytoplasm (UniProt). Locus 8q24.21 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.64 with prostate cancer (MONDO_0008315); Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9223: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9223
- UniProt Q06416: https://www.uniprot.org/uniprotkb/Q06416/entry
- NCBI Gene 5462: https://www.ncbi.nlm.nih.gov/gene/5462
- Ensembl ENSG00000212993: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000212993

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/pou5f1b.json