# PPAT

Source: https://onco.cc/targets/ppat/  
OnCo record `ppat` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPAT (Amidophosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.

## Summary

Catalyses the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.89, animal model 0.56, genetic association 0.60, clinical 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phosphoribosyl pyrophosphate amidotransferase; Amidophosphoribosyltransferase
- Tags: cancer-genes-wave
- Symbol: PPAT
- Class: enzyme
- Biology: Catalyses the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Locus 4q12 (HGNC).
- Where found: Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908); Acute lymphoblastic leukaemia: Open Targets association 0.59 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9238: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9238
- UniProt Q06203: https://www.uniprot.org/uniprotkb/Q06203/entry
- NCBI Gene 5471: https://www.ncbi.nlm.nih.gov/gene/5471
- Ensembl ENSG00000128059: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128059

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/ppat.json