# PPM1B

Source: https://onco.cc/targets/ppm1b/  
OnCo record `ppm1b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPM1B (Protein phosphatase 1B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.78, affected pathway 0.83, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase, Mg2+/Mn2+ dependent 1B; Protein phosphatase 1B; PPC2BETAX; PP2CB; PP2CBETA
- Tags: cancer-genes-wave
- Symbol: PPM1B
- Class: enzyme
- Biology: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signalling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Location: Cytoplasm, cytosol; Membrane (UniProt). Locus 2p21 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9276: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9276
- UniProt O75688: https://www.uniprot.org/uniprotkb/O75688/entry
- NCBI Gene 5495: https://www.ncbi.nlm.nih.gov/gene/5495
- Ensembl ENSG00000138032: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138032

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ppm1b.json