# PPP1R14A

Source: https://onco.cc/targets/ppp1r14a/  
OnCo record `ppp1r14a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.74).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 1 regulatory inhibitor subunit 14A; Protein phosphatase 1 regulatory subunit 14A; CPI-17; PPP1INL
- Tags: cancer-genes-wave
- Symbol: PPP1R14A
- Class: other
- Biology: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Location: Cytoplasm (UniProt). Locus 19q13.1 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.56 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14871: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14871
- UniProt Q96A00: https://www.uniprot.org/uniprotkb/Q96A00/entry
- NCBI Gene 94274: https://www.ncbi.nlm.nih.gov/gene/94274
- Ensembl ENSG00000167641: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167641

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/ppp1r14a.json