# PPP2CA

Source: https://onco.cc/targets/ppp2ca/  
OnCo record `ppp2ca` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP2CA (Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes clinical 0.13, affected pathway 0.78, literature 0.87, genetic association 0.00, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 2 catalytic subunit alpha; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2Calpha; PP2AC
- Tags: cancer-genes-wave
- Symbol: PPP2CA
- Class: enzyme
- Biology: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1. Activates RAF1 by dephosphorylating it at 'Ser-259'. Location: Cytoplasm; Nucleus; Chromosome; Chromosome, centromere (UniProt). Locus 5q31.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.13. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9299: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9299
- UniProt P67775: https://www.uniprot.org/uniprotkb/P67775/entry
- NCBI Gene 5515: https://www.ncbi.nlm.nih.gov/gene/5515
- Ensembl ENSG00000113575: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113575

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ppp2ca.json