# PPP2CB

Source: https://onco.cc/targets/ppp2cb/  
OnCo record `ppp2cb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP2CB (Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes clinical 0.13, affected pathway 0.89, literature 0.38, genetic association 0.03, animal model 0.47).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 2 catalytic subunit beta; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2Abeta
- Tags: cancer-genes-wave
- Symbol: PPP2CB
- Class: enzyme
- Biology: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Location: Cytoplasm; Nucleus; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle pole (UniProt). Locus 8p12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.13. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9300: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9300
- UniProt P62714: https://www.uniprot.org/uniprotkb/P62714/entry
- NCBI Gene 5516: https://www.ncbi.nlm.nih.gov/gene/5516
- Ensembl ENSG00000104695: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104695

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ppp2cb.json