# PPP2R1A

Source: https://onco.cc/targets/ppp2r1a/  
OnCo record `ppp2r1a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP2R1A is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localisation of SGO1 in mitosis.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Ipilimumab/Nivolumab Regimen and Durvalumab/Tremelimumab Regimen. Open Targets scores its association with cancer at 0.81 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.89, genetic association 0.00, somatic mutation 0.97, animal model 0.69). IntOGen calls it a driver in 11 cohorts (10 activating, 1 loss-of-function), covering Adenoid Cystic Carcinoma, Colorectal Adenocarcinoma, Ovarian Epithelial Tumour, Small Cell Lung Cancer, Endometrial Carcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 2 scaffold subunit Aalpha; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PR65A; PP2A-Aalpha; PP2AA
- Tags: cancer-genes-wave
- Symbol: PPP2R1A
- Class: oncogene
- Biology: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localisation of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signalling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. Location: Cytoplasm; Nucleus; Chromosome; Chromosome, centromere (UniProt). Locus 19q13.41 (HGNC).
- Where found: Endometrial cancer: Open Targets association 0.68 with endometrial cancer (MONDO_0011962); IntOGen driver in 4 cohorts (UCEC); Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COADREAD); Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170); IntOGen driver in 1 cohort (OVT); Salivary gland cancers: IntOGen driver in 1 cohort (ACYC); Thyroid cancer: IntOGen driver in 1 cohort (WDTC); Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; IntOGen calls it an activating (Act) driver in 10 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Ovarian Clear Cell Carcinoma.

## Sources

- HGNC HGNC:9302: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9302
- UniProt P30153: https://www.uniprot.org/uniprotkb/P30153/entry
- NCBI Gene 5518: https://www.ncbi.nlm.nih.gov/gene/5518
- Ensembl ENSG00000105568: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105568

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Salivary gland cancers](https://onco.cc/cancers/salivary-gland/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/), [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/ppp2r1a.json