# PPP2R1B

Source: https://onco.cc/targets/ppp2r1b/  
OnCo record `ppp2r1b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.

Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.89, genetic association 0.51, somatic mutation 0.55).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 2 scaffold subunit Abeta; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PR65B; PP2A-Abeta
- Tags: cancer-genes-wave
- Symbol: PPP2R1B
- Class: other
- Biology: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Locus 11q23.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9303: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9303
- UniProt P30154: https://www.uniprot.org/uniprotkb/P30154/entry
- NCBI Gene 5519: https://www.ncbi.nlm.nih.gov/gene/5519
- Ensembl ENSG00000137713: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137713

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ppp2r1b.json