# PPP2R5A

Source: https://onco.cc/targets/ppp2r5a/  
OnCo record `ppp2r5a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP2R5A (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.69, affected pathway 0.89, animal model 0.62, genetic association 0.19).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 2 regulatory subunit B'alpha; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PR61A; B56A; B56alpha
- Tags: cancer-genes-wave
- Symbol: PPP2R5A
- Class: other
- Biology: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. Location: Cytoplasm; Nucleus; Chromosome, centromere (UniProt). Locus 1q32.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9309: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9309
- UniProt Q15172: https://www.uniprot.org/uniprotkb/Q15172/entry
- NCBI Gene 5525: https://www.ncbi.nlm.nih.gov/gene/5525
- Ensembl ENSG00000066027: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000066027

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ppp2r5a.json