# PPP2R5B

Source: https://onco.cc/targets/ppp2r5b/  
OnCo record `ppp2r5b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.89, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 2 regulatory subunit B'beta; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; FLJ35411; B56B; PR61B; B56beta
- Tags: cancer-genes-wave
- Symbol: PPP2R5B
- Class: other
- Biology: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. Location: Cytoplasm (UniProt). Locus 11q13.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9310: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9310
- UniProt Q15173: https://www.uniprot.org/uniprotkb/Q15173/entry
- NCBI Gene 5526: https://www.ncbi.nlm.nih.gov/gene/5526
- Ensembl ENSG00000068971: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000068971

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ppp2r5b.json