# PPP2R5C

Source: https://onco.cc/targets/ppp2r5c/  
OnCo record `ppp2r5c` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PPP2R5C (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signalling pathway through ERK dephosphorylation.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.82, genetic association 0.00, somatic mutation 0.23, animal model 0.32). In OnCo, 1 product record names it (Cologuard Plus).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein phosphatase 2 regulatory subunit B'gamma; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; B56G; PR61G; B56gamma
- Tags: cancer-genes-wave
- Symbol: PPP2R5C
- Class: other
- Biology: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signalling pathway through ERK dephosphorylation. Location: Nucleus; Chromosome, centromere (UniProt). Locus 14q32.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9311: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9311
- UniProt Q13362: https://www.uniprot.org/uniprotkb/Q13362/entry
- NCBI Gene 5527: https://www.ncbi.nlm.nih.gov/gene/5527
- Ensembl ENSG00000078304: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078304

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- drugs: [Cologuard Plus](https://onco.cc/drugs/cologuard-plus/)

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JSON: https://onco.cc/api/v1/entities/ppp2r5c.json