# PRCC

Source: https://onco.cc/targets/prcc/  
OnCo record `prcc` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRCC (Proline-rich protein PRCC) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.

## Summary

May regulate cell cycle progression through interaction with MAD2L2.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.23, somatic mutation 0.80).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: proline rich mitotic checkpoint control factor; Proline-rich protein PRCC; RCCP1
- Tags: cancer-genes-wave
- Symbol: PRCC
- Class: other
- Biology: May regulate cell cycle progression through interaction with MAD2L2. Location: Nucleus (UniProt). Locus 1q23.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9343: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9343
- UniProt Q92733: https://www.uniprot.org/uniprotkb/Q92733/entry
- NCBI Gene 5546: https://www.ncbi.nlm.nih.gov/gene/5546
- Ensembl ENSG00000143294: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143294

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- trials: [Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable and Locally Advanced or Metastatic PRCC](https://onco.cc/trials/nct05043090/), [Savolitinib vs. Sunitinib in MET-driven PRCC.](https://onco.cc/trials/nct03091192/)

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JSON: https://onco.cc/api/v1/entities/prcc.json