# Precision-Panc

Source: https://onco.cc/trials/precision-panc/  
OnCo record `precision-panc` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The UK precision medicine platform for pancreatic cancer, led from Glasgow: profile the tumour at diagnosis, then route the patient to a matching PRIMUS trial.

## Summary

Precision-Panc, led by Andrew Biankin and sponsored by NHS Greater Glasgow and Clyde, opened its master protocol in December 2017. The ISRCTN record lists 27 recruiting sites from Glasgow Royal Infirmary and Aberdeen to the Royal Marsden, UCLH, Addenbrooke's, The Christie, Weston Park, Bristol, Imperial, Nottingham, the Royal Free, Ninewells, St George's, Southampton, Queen Elizabeth Birmingham, King's, the Churchill, Castle Hill, Poole, the Freeman and Bournemouth, a target of 5,000 and an end of recruitment on 29 March 2022; the registry shows it as suspended. Its PRIMUS trials (ISRCTN75002153 PRIMUS 001 first-line, ISRCTN34129115 PRIMUS 002 neoadjuvant, ISRCTN16004234 PRIMUS 004 second-line platform, ISRCTN53212600 PRIMUS 006, and STARPAC2 as PRIMUS 005) tested treatments matched to molecular subtype; PRIMUS 002, 004 and 006 are recorded as stopped and PRIMUS 001 as no longer recruiting. The programme's legacy is a UK network of centres able to take research biopsies and run molecular profiling at diagnosis.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-09-24
- Also known as: Precision Panc master protocol; PRIMUS trials; ISRCTN14879538
- Tags: uk; precision-medicine; platform; pancreatic
- Registry id: ISRCTN14879538
- Phase: platform
- Setting: Master protocol taking extra tissue at diagnostic biopsy or a dedicated research biopsy from people with pancreatic cancer at 27 UK sites, for molecular profiling and allocation to the PRIMUS treatment trials; recruitment 14 December 2017 to 29 March 2022, target 5,000
- Sponsor: NHS Greater Glasgow and Clyde
- Enrolled: 5000

## Sources

- ISRCTN14879538: Precision Panc: https://www.isrctn.com/ISRCTN14879538
- STARPAC2 protocol (PRIMUS 005), BMC Cancer 2025: https://europepmc.org/article/MED/39833722

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- fronts: [Diagnostics & Biomarkers](https://onco.cc/fronts/diagnostics/), [Targeted Therapy](https://onco.cc/fronts/targeted-therapy/)
- targets: [BRCA1 / BRCA2 (HRD)](https://onco.cc/targets/brca/), [KRAS](https://onco.cc/targets/kras/)
- institutions: [Aberdeen Royal Infirmary](https://onco.cc/institutions/aberdeen-royal-infirmary/), [Addenbrooke's Hospital, Cambridge University Hospitals](https://onco.cc/institutions/addenbrookes-cambridge/), [Beatson West of Scotland Cancer Centre / CRUK Scotland Institute](https://onco.cc/institutions/beatson-glasgow/), [Castle Hill Hospital, Hull (Queen's Centre)](https://onco.cc/institutions/hull-castle-hill/), [Glasgow Royal Infirmary](https://onco.cc/institutions/glasgow-royal-infirmary/), [Imperial College Healthcare NHS Trust / Imperial College London Cancer Research](https://onco.cc/institutions/imperial-cancer-centre/), [King's College Hospital, London](https://onco.cc/institutions/kings-college-hospital-london/), [Newcastle Cancer Centre / Northern Centre for Cancer Care](https://onco.cc/institutions/newcastle-cancer-centre/), [Ninewells Hospital, Dundee](https://onco.cc/institutions/ninewells-dundee/), [Nottingham University Hospitals Cancer Centre (City Hospital)](https://onco.cc/institutions/nottingham-cancer-centre/), [Oxford Cancer (Oxford University Hospitals and University of Oxford)](https://onco.cc/institutions/oxford-cancer/), [Royal Free Hospital, Royal Free London NHS Foundation Trust](https://onco.cc/institutions/royal-free-hospital/), [The Christie NHS Foundation Trust](https://onco.cc/institutions/the-christie/), [The Royal Marsden](https://onco.cc/institutions/royal-marsden/), [University College London Hospitals / UCL Cancer Institute](https://onco.cc/institutions/uclh/), [University Hospital Southampton / Centre for Cancer Immunology](https://onco.cc/institutions/southampton-cancer/), [University Hospitals Birmingham / University of Birmingham Cancer Research Centre](https://onco.cc/institutions/birmingham-cancer-centre/), [Weston Park Cancer Centre, Sheffield Teaching Hospitals](https://onco.cc/institutions/weston-park-sheffield/), [Wolfson Wohl Cancer Research Centre, University of Glasgow](https://onco.cc/institutions/wolfson-wohl-cancer-research-centre/)
- terms: [Genomic profiling](https://onco.cc/terms/genomic-profiling/)
- people: [Andrew Biankin](https://onco.cc/people/andrew-biankin/)

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