# PRKCH

Source: https://onco.cc/targets/prkch/  
OnCo record `prkch` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRKCH (PRKCH upstream open reading frame 2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Systemic mastocytosis and 1 more.

## Summary

Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF. Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner. In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes clinical 0.92, affected pathway 0.76, literature 0.92, genetic association 0.07, animal model 0.42).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein kinase C eta; PRKCH upstream open reading frame 2; PKC-L; PRKCL
- Tags: cancer-genes-wave
- Symbol: PRKCH
- Class: other
- Biology: Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF. Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner. In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ. Locus 14q23.1 (HGNC).
- Where found: Leukaemia: Open Targets association 0.63 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.62 with myeloproliferative neoplasm (MONDO_0020076); Systemic mastocytosis: Open Targets association 0.54 with systemic mastocytosis (MONDO_0016586); Acute myeloid leukaemia: Open Targets association 0.56 with acute myeloid leukaemia (MONDO_0018874)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.94. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9403: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9403
- UniProt C0HM02: https://www.uniprot.org/uniprotkb/C0HM02/entry
- NCBI Gene 5583: https://www.ncbi.nlm.nih.gov/gene/5583
- Ensembl ENSG00000027075: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000027075

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Systemic mastocytosis](https://onco.cc/cancers/systemic-mastocytosis/)

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JSON: https://onco.cc/api/v1/entities/prkch.json