# PRKCI

Source: https://onco.cc/targets/prkci/  
OnCo record `prkci` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRKCI (Protein kinase C iota type) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Systemic mastocytosis and 1 more.

## Summary

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukaemia cells, protecting leukaemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.54, clinical 0.92).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein kinase C iota; Protein kinase C iota type; DXS1179E
- Tags: cancer-genes-wave
- Symbol: PRKCI
- Class: kinase
- Biology: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukaemia cells, protecting leukaemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Location: Cytoplasm; Membrane; Endosome; Nucleus (UniProt). Locus 3q26.2 (HGNC).
- Where found: Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.56 with myeloproliferative neoplasm (MONDO_0020076); Systemic mastocytosis: Open Targets association 0.54 with systemic mastocytosis (MONDO_0016586); Acute myeloid leukaemia: Open Targets association 0.56 with acute myeloid leukaemia (MONDO_0018874)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.94. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9404: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9404
- UniProt P41743: https://www.uniprot.org/uniprotkb/P41743/entry
- NCBI Gene 5584: https://www.ncbi.nlm.nih.gov/gene/5584
- Ensembl ENSG00000163558: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163558

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Systemic mastocytosis](https://onco.cc/cancers/systemic-mastocytosis/)

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JSON: https://onco.cc/api/v1/entities/prkci.json