# PRKD2

Source: https://onco.cc/targets/prkd2/  
OnCo record `prkd2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRKD2 (Serine/threonine-protein kinase D2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma.

## Summary

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signalling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signalling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signalling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein kinase D2; Serine/threonine-protein kinase D2; PKD2; HSPC187; DKFZP586E0820
- Tags: cancer-genes-wave
- Symbol: PRKD2
- Class: kinase
- Biology: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signalling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signalling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signalling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. Location: Cytoplasm; Cell membrane; Nucleus; Golgi apparatus, trans-Golgi network (UniProt). Locus 19q13.32 (HGNC).
- Where found: Multiple myeloma: IntOGen driver in 1 cohort (PCM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17293: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17293
- UniProt Q9BZL6: https://www.uniprot.org/uniprotkb/Q9BZL6/entry
- NCBI Gene 25865: https://www.ncbi.nlm.nih.gov/gene/25865
- Ensembl ENSG00000105287: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105287

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/)

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JSON: https://onco.cc/api/v1/entities/prkd2.json