# PRKD3

Source: https://onco.cc/targets/prkd3/  
OnCo record `prkd3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRKD3 (Serine/threonine-protein kinase D3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Systemic mastocytosis and 1 more.

## Summary

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.96, animal model 0.42, genetic association 0.00, clinical 0.92).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein kinase D3; Serine/threonine-protein kinase D3; PKD3; EPK2; PRKCN
- Tags: cancer-genes-wave
- Symbol: PRKD3
- Class: kinase
- Biology: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress. Location: Cytoplasm; Membrane (UniProt). Locus 2p22.2 (HGNC).
- Where found: Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.56 with myeloproliferative neoplasm (MONDO_0020076); Systemic mastocytosis: Open Targets association 0.54 with systemic mastocytosis (MONDO_0016586); Acute myeloid leukaemia: Open Targets association 0.56 with acute myeloid leukaemia (MONDO_0018874)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.94. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9408: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9408
- UniProt O94806: https://www.uniprot.org/uniprotkb/O94806/entry
- NCBI Gene 23683: https://www.ncbi.nlm.nih.gov/gene/23683
- Ensembl ENSG00000115825: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115825

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Systemic mastocytosis](https://onco.cc/cancers/systemic-mastocytosis/)

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JSON: https://onco.cc/api/v1/entities/prkd3.json