# PRKDC

Source: https://onco.cc/targets/prkdc/  
OnCo record `prkdc` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRKDC (DNA-dependent protein kinase catalytic subunit) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma, Non-small-cell lung cancer and Diffuse large B-cell lymphoma.

## Summary

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties.

CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Anti-CTLA-4 Monoclonal Antibody and Anti-PD1 Monoclonal Antibody.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein kinase, DNA-activated, catalytic subunit; DNA-dependent protein kinase catalytic subunit; DNPK1; p350; DNAPK; XRCC7; DNA-PKcs; DNAPKc; DNA-PKC; p460; HYRC1
- Tags: cancer-genes-wave
- Symbol: PRKDC
- Class: kinase
- Biology: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. Acts as a scaffold protein to aid the localisation of DNA repair proteins to the site of damage. Location: Nucleus; Nucleus, nucleolus; Cytoplasm, cytosol (UniProt). Locus 8q11.21 (HGNC).
- Where found: Melanoma: CIViC evidence names this disease; Non-small-cell lung cancer: CIViC evidence names this disease; Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9413: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9413
- UniProt P78527: https://www.uniprot.org/uniprotkb/P78527/entry
- NCBI Gene 5591: https://www.ncbi.nlm.nih.gov/gene/5591
- Ensembl ENSG00000253729: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000253729

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Melanoma](https://onco.cc/cancers/melanoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/prkdc.json