# PROM1

Source: https://onco.cc/targets/prom1/  
OnCo record `prom1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.

## Summary

May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: prominin 1; Prominin-1; AC133; CD133; RP41; CORD12; PROML1; MCDR2; STGD4
- Tags: cancer-genes-wave
- Symbol: PROM1
- Class: other
- Biology: May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signalling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Location: Apical cell membrane; Cell projection, microvillus membrane; Cell projection, cilium, photoreceptor outer segment; Endoplasmic reticulum (UniProt). Locus 4p15.32 (HGNC).
- Where found: Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9454: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9454
- UniProt O43490: https://www.uniprot.org/uniprotkb/O43490/entry
- NCBI Gene 8842: https://www.ncbi.nlm.nih.gov/gene/8842
- Ensembl ENSG00000007062: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000007062

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/prom1.json