# PROMISE (pan-cancer liquid biopsy proof of concept, Chinese Academy of Medical Sciences)

Source: https://onco.cc/trials/promise-cams/  
OnCo record `promise-cams` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A Chinese study that compared three kinds of blood test, reading DNA mutations, DNA methylation and microRNA, for finding several cancers early.

## Summary

PROMISE (NCT04972201) is an observational study sponsored by Cancer Institute and Hospital, Chinese Academy of Medical Sciences with Guangzhou Burning Rock Dx Co., Ltd. It evaluated three prototype assays (cell-free DNA mutation, cell-free DNA methylation and microRNA expression) for early detection of several cancers, to choose which to develop.

The registry record, read on 29 October 2026, gives its status as completed, with 2,305 participants enrolled, a start on 1 June 2021 and primary completion on 31 March 2022.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-10-29
- Also known as: PROMISE
- Registry id: NCT04972201
- Phase: observational
- Setting: People with cancer and healthy people at the Cancer Institute and Hospital of the Chinese Academy of Medical Sciences, comparing three prototype blood assays
- Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences with Guangzhou Burning Rock Dx Co., Ltd.
- Enrolled: 2305

## Sources

- ClinicalTrials.gov NCT04972201: https://clinicaltrials.gov/study/NCT04972201

## Connected records

- fronts: [Early Detection & Screening](https://onco.cc/fronts/early-detection/)
- technologies: [Liquid biopsy (ctDNA)](https://onco.cc/technologies/liquid-biopsy/), [Multi-cancer early detection (MCED)](https://onco.cc/technologies/mced/)
- drugs: [OverC Multi-Cancer Detection Blood Test](https://onco.cc/drugs/overc-mcdbt/)
- companies: [Burning Rock Biotech](https://onco.cc/companies/burning-rock/)
- key papers: [Exploration of multi-omics liquid biopsy approaches for multi-cancer early detection: The PROMISE study](https://onco.cc/key-papers/paper-promise-innovation-2026/)

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