# PRPS1

Source: https://onco.cc/targets/prps1/  
OnCo record `prps1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRPS1 (Ribose-phosphate pyrophosphokinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute lymphoblastic leukaemia.

## Summary

Catalyses the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

CIViC holds 45 clinical evidence items and 0 assertions across 21 variants, naming Mercaptopurine, Thioguanine, Daunorubicin and Cytarabine and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: phosphoribosyl pyrophosphate synthetase 1; Ribose-phosphate pyrophosphokinase 1; CMTX5; DFNX1; PRS-I; PPRibP; DFN2
- Tags: cancer-genes-wave
- Symbol: PRPS1
- Class: kinase
- Biology: Catalyses the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Locus Xq22.3 (HGNC).
- Where found: Acute lymphoblastic leukaemia: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 7 therapies; CIViC holds 45 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9462: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9462
- UniProt P60891: https://www.uniprot.org/uniprotkb/P60891/entry
- NCBI Gene 5631: https://www.ncbi.nlm.nih.gov/gene/5631
- Ensembl ENSG00000147224: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147224

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/)

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JSON: https://onco.cc/api/v1/entities/prps1.json