# Prudence A. Francis

Source: https://onco.cc/people/prudence-francis/  
OnCo record `prudence-francis` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led SOFT and TEXT, the trials that showed ovarian suppression plus exemestane helps young women with breast cancer.

## Summary

Prudence Francis chaired the IBCSG SOFT trial and co-led the joint SOFT/TEXT analysis showing that adding ovarian function suppression to tamoxifen, or using it with exemestane, reduces recurrence and improves survival in premenopausal HR-positive breast cancer. The results set the standard for adjuvant endocrine therapy in younger women. She leads breast medical oncology at Peter Mac and Breast Cancer Trials studies in Australia and New Zealand.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: breast; premenopausal; ibcsg
- Role: Head of Breast Medical Oncology, Peter MacCallum Cancer Centre
- Specialisms: Premenopausal breast cancer; Ovarian function suppression; Adjuvant endocrine therapy

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Francis%20PA%5BAuthor%5D%20SOFT%20TEXT

## Connected records

- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)
- technologies: [Endocrine therapy (SERMs, AIs, SERDs)](https://onco.cc/technologies/endocrine-therapy/)
- companies: [Breast Cancer Trials](https://onco.cc/companies/breast-cancer-trials/)
- institutions: [Peter MacCallum Cancer Centre](https://onco.cc/institutions/peter-mac/)
- trials: [SOFT & TEXT](https://onco.cc/trials/soft-text/)

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JSON: https://onco.cc/api/v1/entities/prudence-francis.json