# PRUNE2

Source: https://onco.cc/targets/prune2/  
OnCo record `prune2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PRUNE2 (Protein prune homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroblastoma.

## Summary

May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Neuroblastoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: prune homolog 2 with BCH domain; Protein prune homolog 2; BMCC1; BNIPXL; A214N16.3; bA214N16.3; C9orf65; KIAA0367
- Tags: cancer-genes-wave
- Symbol: PRUNE2
- Class: tumor-suppressor
- Biology: May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells. Location: Cytoplasm (UniProt). Locus 9q21.2 (HGNC).
- Where found: Neuroblastoma: IntOGen driver in 1 cohort (NBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25209: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25209
- UniProt Q8WUY3: https://www.uniprot.org/uniprotkb/Q8WUY3/entry
- NCBI Gene 158471: https://www.ncbi.nlm.nih.gov/gene/158471
- Ensembl ENSG00000106772: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106772

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Neuroblastoma (paediatric)](https://onco.cc/cancers/neuroblastoma/)

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JSON: https://onco.cc/api/v1/entities/prune2.json