# PSCA

Source: https://onco.cc/targets/psca/  
OnCo record `psca` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.

## Summary

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.64, genetic association 0.69, clinical 0.17).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: prostate stem cell antigen; Prostate stem cell antigen; lncPSCA
- Tags: cancer-genes-wave
- Symbol: PSCA
- Class: other
- Biology: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signalling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. Location: Cell membrane (UniProt). Locus 8q24.3 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: Open Targets association 0.53 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.17. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9500: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9500
- UniProt O43653: https://www.uniprot.org/uniprotkb/O43653/entry
- NCBI Gene 8000: https://www.ncbi.nlm.nih.gov/gene/8000
- Ensembl ENSG00000167653: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167653

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/psca.json