# PSIP1

Source: https://onco.cc/targets/psip1/  
OnCo record `psip1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PSIP1 (PC4 and SFRS1-interacting protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Gallbladder cancer.

## Summary

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fibre cell terminal differentiation.

Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.25, literature 0.97, genetic association 0.13, somatic mutation 0.87, animal model 0.25). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Gallbladder Cancer.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: PC4 and SRSF1 interacting protein 1; PC4 and SFRS1-interacting protein; p52; LEDGF; p75; DFS70; PSIP2
- Tags: cancer-genes-wave
- Symbol: PSIP1
- Class: tumor-suppressor
- Biology: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fibre cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Location: Nucleus (UniProt). Locus 9p22.3 (HGNC).
- Where found: Bladder & urothelial cancer: Open Targets association 0.51 with urinary bladder cancer (MONDO_0001187); IntOGen driver in 1 cohort (BLCA); Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575); Gallbladder cancer: IntOGen driver in 1 cohort (GBC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9527: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9527
- UniProt O75475: https://www.uniprot.org/uniprotkb/O75475/entry
- NCBI Gene 11168: https://www.ncbi.nlm.nih.gov/gene/11168
- Ensembl ENSG00000164985: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164985

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gallbladder cancer](https://onco.cc/cancers/gallbladder/)
- pathways: [Menin / KMT2A (HOXA9-MEIS1 axis)](https://onco.cc/pathways/menin-kmt2a/)

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JSON: https://onco.cc/api/v1/entities/psip1.json