# PSPC1

Source: https://onco.cc/targets/pspc1/  
OnCo record `pspc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PSPC1 (Paraspeckle component 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.

## Summary

RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: paraspeckle component 1; Paraspeckle component 1; PSP1; FLJ10955
- Tags: cancer-genes-wave
- Symbol: PSPC1
- Class: oncogene
- Biology: RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Location: Nucleus speckle; Nucleus, nucleolus; Nucleus matrix; Cytoplasm (UniProt). Locus 13q12.11 (HGNC).
- Where found: Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20320: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20320
- UniProt Q8WXF1: https://www.uniprot.org/uniprotkb/Q8WXF1/entry
- NCBI Gene 55269: https://www.ncbi.nlm.nih.gov/gene/55269
- Ensembl ENSG00000121390: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121390

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/pspc1.json